New research suggests that patients who come off popular slimming jabs like Mounjaro or Wegovy may regain lost weight much more quickly than those who end conventional diet and exercise programs.
Findings released in a prominent medical journal points out that while overweight individuals frequently drop about a fifth of their total mass while on the medication, the mass comes back at an average rate of nearly a kilo each month upon discontinuation.
"Individuals purchasing such drugs should be informed of the danger of quick rebound weight gain when the therapy concludes," stated expert Dr. Susan Jebb.
Such speed of regain means a reversion to pre-treatment mass within about a year and a half.
Comparing Therapies
The research, which reviewed 37 of studies involving over 9,000 of participants, contrasted the outcomes of GLP-1 agonists with other pills.
Researchers emphasize that individuals who shed pounds through diet and exercise usually see a slower weight regain—around 0.1 kg a month—once they finish.
The Reason for the Fast Regain
Experts suggest the way of the jabs accounts for the heightened rebound.
These medications imitate a body's own chemical called GLP-1, which moderates hunger.
"Long-term administration of the hormone levels several times higher than normal could lead to the body to produce less of its own natural hormone, and could lessen responsiveness to its actions," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication results in appetite is unsuppressed, making overeating a significant risk."
A Chronic Issue?
The NHS advise the jabs for individuals with obesity-related health risks, alongside recommended lifestyle changes.
A number of clinicians contend that, due to the high risk of weight regain, the treatment is often long-term.
This view is reinforced by drug manufacturers, who state that the results "emphasize the chronic nature of obesity," akin to managing diseases like hypertension.
Patient Experiences
People who have discontinued the medication describe a sudden resurgence of cravings.
"I experienced a switch activating and you're instantly ravenous," recalled a patient.
This challenge is worsened if users have not established lasting dietary or behavioural changes during therapy.
Significant Adoption
Recent estimates indicate that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with demand being substantial.
- Use is higher among females compared to men.
- The 40s and 50s demographic shows the greatest level of interest.
- Many obtain the drugs through private prescriptions rather than public health services.
In conclusion, clinicians stress that while the jabs are effective agents for shedding pounds, they are not a permanent fix and long-term success hinges on ongoing lifestyle management.
